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KMID : 0380620070390030323
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Korean Journal of Food Science and Technology
2007 Volume.39 No. 3 p.323 ~ p.329
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Physiological Activity/Nutrition : Effects of Fermented Milk with Hot Water Extract from Acanthopanax senticosus and Codonopsis Lanceolata on the Immune Status of Mouse
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Lim Sang-Dong
Seong Ki-Seung
Kim Kee-Sung
Han Dong-Un
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Abstract
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We investigated the immunomodulatory actions of water extract from Acanthopanax senticosus in male ICR mice. The mice were treated with fermented milk containing three added doses of freeze dried extract: 3 mg/kg (A), 9 mg/kg (B), and 27 mg/kg (C) of body weight with Acanthopanax senticosus: Codonopsis lanceolata (8:2) for 7 and 10 weeks, respectively. Organ weights, plaque-forming cell tests, agglutination tests, IgG tests, differential white cell counts, and histological tests were performed at the 7th and 10th weeks of dietary treatment. There were no significant differences in body weight and organ weight. The spleen indices of group B at 7 weeks and group C at 10 weeks were significantly higher than those of the control group (p<0.05). For the plaque-forming cell test, groups B and C at 7 weeks, and group C at 10 weeks, showed significant increases over the control group (p<0.05). The agglutination test decreased with an extended experimental period. Groups A, B, and C at 7 weeks, and groups B and C at 10 weeks, had greater antibody responses to sheep red blood cells (SRBC) than the control group. The IgG antibody production of group C at 7 weeks and groups B and C at 10 weeks were significantly higher than the control group (p<0.05). In groups B and C, lymphocyte percentage was higher than the control group, and their spleen and thymus tissues showed active immune reactions.
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KEYWORD
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Acanthopanax senticosus, Codonopsis Lanceolata, immunomodulatory activity, fermented milk
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